Peroxisome proliferator-activated receptor alpha （PPARα） is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor （RXR） to regulate gene expression. PPARα is located primarily in the liver, adipose tissue, kidney, heart, skeletal muscle and large intestine where it is thought to regulate fatty acid synthesis and oxidation, gluconeogenesis, ketogenesis and lipoprotein assembly. The human gene encoding PPARα has been localized to chromosome 22 （22q12-13.1）. Species Gene Symbol Gene Accession No. Protein Accession No.Human PPARA NM_001001928 Q07869Mouse Ppara NM_011144 P23204Rat Ppara NM_013196 P37230 抑制剂 GW 6471 分子量:635.68 分子式:C35H36F3N3O5Solubility:Soluble to 100 mM in DMSO and to 100 mM in ethanolPurity:>98 % 10mg ，50mg 规格CAS No:[436159-64-7] Chemical Name:[（2S）-2-[[（1Z）-1-Methyl-3-oxo-3-[4-（trifluoromethyl）phenyl]-1-propenyl]amino]-3-[4-[2-（5-methyl-2-phenyl-4-oxazolyl）ethoxy]phenyl]propyl]-carbamic acid ethyl ester Sold with the permission of GlaxoSmithKline 过氧化物酶增殖活化受体α抑制剂 GW6471 PPARα 系列产品PPARα抑制剂 that inhibits activation with an IC50 value of 0.24μM. MK 886 分子量:472.08 分子式:C27H34ClNO2SSolubility:Soluble to 5 mM in ethanol and to 100 mM in DMSOPurity:>98 % 10mg ，50mg 规格Storage:Store at RTCAS No:[118414-82-7]Chemical Name: 1-[（4-Chlorophenyl）methyl]-3-[（1,1-dimethylethyl）thio]-α,α-dimethyl-5-（1-methylethyl）-1H-Indole-2-propanoic acid别名：L-663,536An inhibitor of leukotriene biosynthesis （IC50 = 3 nM in human polymorphonuclear leukocytes）. Acts by inhibiting 5-lipoxygenase-activating protein （FLAP） （IC50 = 30 nM for inhibition of [125I]-L-691,678 photoaffinity labelling）. Also moderately potent PPARα抑制剂 （IC50 = 0.5-1μM）. Orally activein vivo. 激动剂 GW 7647分子量:502.75 分子式：C29H46N2O3SSolubility:Soluble to 25 mM in ethanol and to 100 mM in DMSO Purity:>99 % 10mg ，50mg 规格CAS No:[265129-71-3]Chemical Name: 2-[[4-[2-[[（Cyclohexylamino）carbonyl]（4-cyclohexylbutyl）amino]ethyl]phenyl]thio]-2-methylpropanoic acidPotent and highly selective PPARαagonist （EC50 values are 6, 1100 and 6200 nM for human PPARα, PPARγand PPARδreceptors respectively）. Modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubulesin vitro. Has lipid-lowering effects following oral administrationin vivo. Reduces NO production in macrophages; exhibits anti-inflammatory properties Fenofibrate分子量：360.83 分子式：C20H21ClO4Solubility:Soluble to 100 mM in DMSO and to 100 mM in ethanolPurity:>99 % 50mg 规格Storage:Store at RTCAS No:[49562-28-9]Chemical Name: 2-[4-（4-Chlorobenzoyl）phenoxy]-2-methylpropanoic acid isopropyl esterPPARα agonist; hypolipidemic. Attenuates insulin resistance and increases high-density lipoprotein-cholesterol in db/db mice. 296638 [49562-28-9] Fenofibrate 294030 Fenofibrate Imp. F （EP）: （4-Chlorophenyl）[4-（1-methyl-ethoxy 294029 Fenofibrate Imp. E （EP）: Ethyl 2-[4-（4-Chlorobenzoyl）-phenox 294028 Fenofibrate Imp. D （EP）: Methyl 2-[4-（4-Chlorobenzoyl）-pheno 294027 Fenofibrate Imp. C （EP）: （3RS）-3-[4-（4-Chlorobenzoyl）-phenox 294026 Fenofibrate Imp. A （EP）: （4-Chlorophenyl）（4-hydroxyphenyl）me 294025 Fenofibrate 290762 Fenofibrate impurity G 290761 Fenofibrate impurity B 290760 Fenofibrate impurity A 290759 Fenofibrate 288620 [49562-28-9] Fenofibrate 261137 Fenofibrate-d6 261136 49562-28-9 Fenofibrate 259465 Dihydro Fenofibrate-d6 259464 61001-99-8 Dihydro Fenofibrate 257408 856676-23-8 Choline Fenofibrate Oleylethanolamide分子量:325.53 分子式：C20H39NO2Purity:>99 % 10mg ，50mg 规格Storage:Store at +4°CCAS No:[111-58-0]Chemical Name: （9Z）-N-（2-Hydroxyethyl）-9-octadecenamide Palmitoylethanolamide分子量：299.5 分子式：C18N37NO2Solubility:Soluble to 20 mM in DMSO and to 25 mM in ethanolStorage:Store at RT 10mg ，50mg 规格 CAS No:[544-31-0]别名: PEA Chemical Name: N-（2-Hydroxyethyl）hexadecanamid WY 14643 分子量：323.8 分子式：C14H14ClN3O2SSolubility:Soluble to 100 mM in DMSOPurity:>98 % 10mg ，50mg 规格 Storage:Store at RTCAS No:[50892-23-4] Chemical Name: [[4-Chloro-6-[（2,3-dimethylphenyl）amino]-2-pyrimidinyl]thio]acetic acid 其它相关产品： PPARγPeroxisome proliferator-activated receptor gamma （PPARγ） is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor （RXR） to regulate gene expression. PPARγ is located primarily in the adipose tissue, lymphoid tissue, colon, liver and heart and is thought to regulate adipocyte differentiation and glucose homeostasis. PPARγ has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. The human gene encoding PPARγ has been localized to chromosome 3 （3p25）. PPARγ Products激动剂 Ciglitazone Selective PPARγ agonistGW 1929 hydrochloride Selective PPARγ agonist. Orally activeLG 100754M.Wt:396.56 Formula:C26H36O3Solubility:Soluble to 100 mM in DMSO and to 50 mM in ethanolPurity:>99 % 10mg ，50mg 规格CAS No:[180713-37-5]Chemical Name: （2E,4E,6Z）-3-Methyl-7-（5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl）-2,4,6-octatrienoic acidNovel RXR:PPARγagonist; sensitizes PPARγby enhancing its ligand binding activity. Also activates RXR:RAR and RXR:PPARαheterodimers in cotransfection assays. Displays selectivity over other permissive heterodimers such as RXR:LXRαand RXR:BAR/FXR. Exhibits antidiabetic propertiesin vivo. nTZDpa Potent, selective PPARγ partial agonistPioglitazone hydrochlorideNew product Selective PPARγ agonist; antidiabetic agent15-deoxy-Δ-12,14-Prostaglandin J2 Endogenous PPARγ agonistS26948New productPrices displayed reflect a 25% discount off list price Selective PPARγ agonist; antidiabetic agentTroglitazone Selective PPARγ agonist; antidiabetic agent Ant激动剂： BADGE PPARγ 抑制剂GW 9662 Selective PPARγ 抑制剂分子量：276.68 分子式：C13H19N2O3ClSolubility:Soluble to 25 mM in ethanolPurity:>98 % 10mg ，50mg 规格Storage:Store at RTCAS No:[22978-25-2]Chemical Name: 2-Chloro-5-nitro-N-phenylbenzamideSelective PPARγ 抑制剂 （IC50 values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively）. Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range （1-2 μM）, therefore is more potent than BADGE . Anticancer, inhibits growth of human mammary tumor cell lines. SR 202 Selective PPARγ 抑制剂; antidiabetic and antiobesity agentT 0070907 Highly potent and selective PPARγ 抑制剂OtherGenistein PPARγ ligand. Also estrogen receptor ligand and EGFR inhibitor Peroxisome proliferator-activated receptor delta （PPARδ）, also known as PPARβ, is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor （RXR） to regulate gene expression.PPARδ displays a ubiquitous expression pattern and is thought to regulate placental and gut development, fatty acid oxidation, adaptive thermogenesis, control of cell proliferation and differentiation and tissue repair. The human gene encoding PPARδ has been localized to chromosome 6 （6p21.2）. PPARδ Products激动剂GW 0742 Highly selective, potent PPARδ agonistL-165,041 Potent PPARδ agonistAnt激动剂GSK 0660 Selective PPARδ 抑制剂GSK 3787 Potent and selective PPARδ 抑制剂ModulatorsRetinoic acid Positive modulator of PPARδ. Also retinoic acid receptor agonist Antibodies and Blocking PeptidesAnti-PPARδ Antibody recognizing PPARδ
